Order OtoGenome™ Test (110 Genes) for Hearing Loss and Related Syndromes
Hearing loss has an incidence of 1 in 250 births and over half of these children have a genetic etiology. The comprehensive approach of the OtoGenome™ Test now makes it possible to sequence 109 genes known to cause nonsyndromic hearing loss and syndromes that can present as nonsyndromic such as Usher, Pendred, Jervell and Lange-Nielsen (JLNS), and Branchio-Oto-Renal syndrome (BOR). Read more about this test.
Requisition Form
All samples must be accompanied with a completed requisition form. Please make sure any identifiers used on the specimens are provided on the paperwork. Consent page should be signed by a health care provider. Any incomplete or missing paperwork may delay the start of testing.
Test Detail
ACTG1, ADCY1, ADGRV1, ALMS1, ATP6V1B1, BCS1L, BSND, CABP2, CACNA1D, CATSPER2*, CCDC50, CD164, CDC14A, CDH23, CEACAM16, CEP78, CHD7, CIB2, CLDN14, CLIC5, CLPP, CLRN1, COCH, COL11A2, COL4A3, COL4A4, COL4A5, DFNA5, DFNB59, DIABLO, DIAPH1, EDN3, EDNRB, EPS8, ESPN, ESRRB, EYA1, EYA4, GIPC3, GJB2, GJB6, GPSM2, GRHL2, GRXCR1, HARS, HARS2, HGF, HSD17B4, ILDR1, KARS, KCNE1, KCNQ1, KCNQ4, KITLG, LARS2, LHFPL5, LOXHD1, LRTOMT, MARVELD2, MIR96, MITF, MSRB3, MTRNR1, MTTS1, MYH14, MYH9, MYO15A, MYO3A, MYO6, MYO7A, NLRP3, OSBPL2, OTOA, OTOF, OTOG, OTOGL, P2RX2, PAX3, PCDH15, PDZD7, POU3F4, POU4F3, PRPS1, RDX, RIPOR2, S1PR2, SERPINB6, SIX1, SLC26A4, SLC52A2, SLC52A3, SLITRK6, SMPX, SNAI2, SOX10, STRC, SYNE4, TBC1D24, TECTA, TIMM8A, TMC1, TMIE, TMPRSS3, TPRN, TRIOBP, USH1C, USH1G, USH2A, WFS1, WHRN
*Included for deletion purposes only
- Next Generation Sequencing (copy number analysis included when data meets quality standards)
- Sanger Confirmation
- STRC copy number analysis via droplet digital PCR
- GJB6 (DFNB1) deletion analysis via droplet digital PCR
Ordering
lmOto-pnlBv4_L
8-12 weeks
7ml of whole blood (3–5ml for an infant) in a lavender top tube (K2EDTA or K3EDTA)
OR
10 ug of DNA at a minimum concentration of 25 ng/ul (please provide DNA concentration)
Billing Information
The Laboratory for Molecular Medicine offers several billing options for our clients and their patients; however, we do not bill insurance companies and are unable to begin testing without accurate billing information.
81430 (1), 81431 (1)
$3,800
For questions, please contact us at 617-768-8500 or by email.
