Scott Weiss, MD, MS

"Personalized medicine is being able to translate the revolution in molecular genomic diagnostics, prognostics, and therapeutics into clinical practice. Partners Personalized Medicine’s mission is to enable this process for researchers, clinicians and patients at Partners Health Care. I was recruited to be the Director of Partners Personalized Medicine after a competitive search across Partners Health Care. It has been an incredible privilege for me to lead the Center, and to work with our dedicated faculty and staff, who are excited about our mission, and all that we are doing to advance personalized medicine at Partners. We believe we have one of the most exciting programs in personalized medicine in the US, and it is because of the incredibly dedicated staff of the Center that we are so successful in executing on our shared vision." -Scott T. Weiss

Scott Weiss is the Scientific Director of Partners HealthCare Personalized Medicine wherehe supervises a faculty of 6 and a staff of over 100 who are dedicated to translating the results of human genome research into clinical medical practice. His laboratory has close working relationships with the Department of Environmental Health at the Harvard School of Public Health, where he is a Professor of Environmental Health (Respiratory Biology Program), the Biostatistics Department at HSPH, the Pulmonary and Critical Care Division, and the Immunology Division, Department of Medicine, in Brigham and Women’s Hospital.

Biography

As the leader of Partners Personalized Medicine, Scott has developed core laboratories to serve the investigative community at MGH and BWH over the past 10 years. The Translational Genomics Core serves roughly 50 investigators/year and supports over 100 million dollars in NIH grants. We have built the Partners Biobank that has serum, plasma and DNA and is linked to the electronic medical record. The Biobank has over 100,000 consented subjects with samples and 36,000 subjects with genomic data and over 100 investigators receiving free GWAS data and or samples each year. The Biobank supports over 200 million dollars in NIH funded research. Finally, as a result of these resources Partners Personalized Medicine has obtained 73 million dollars in NIH grants for participation in the eMERGE network and the All of Us program.

Scott is currently funded by the NIH and has been for the past 43 years. During this time, he has been PI on over 50 grants and has made over 300 million dollars for Brigham and Women’s Hospital in indirect costs. Scott has collaborated with a variety of investigators on cooperative studies such as the Childhood Asthma Management Program (CAMP), SHARE, ABRIDGE, EVE, and TopMed and has served in an administrative capacity with the NHLBI for a variety of genetic epidemiologic programs including the Special Emphasis Panel on the Use of NHLBI Specimens, the Oversight Committee for the Collaborative Study on the Genetics of Asthma, the NHLBI Genotyping Service Study Section, the T-32 training grant study section, over 30 NHLBI workshops, and the oversight panel for the Genotyping and Sequencing Service. Scott is the Co-Principal Investigator of the only training program in the Clinical and Genetic Epidemiology of Lung Diseases (HL-07427). He has trained a total of 51 investigators; 13 of these trainees have reached the rank of professor, and most remain in academic medicine. Scott has authored or co-authored over 800 papers and co-written and co-edited four books, including a comprehensive textbook of Respiratory Genetics. He has been a recipient of an NHLBI MERIT award. Scott’s career H index is 151. He was identified as being in the top 0.004% of biomedical researchers in the world in terms of impact during the period of 1996-2011 (Eur J Clin Invest.2013 Dec; 43(12): 1339-65 PMID:24134636).

Publications

Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013;8(2):e56179. doi: 10.1371/journal.pone.0056179. Epub 2013 Feb 14. PMID: 23457522.
Wu Ac, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M, Nakamura Y, Qiu W, Weiss ST, Tantisira K. Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics. J Allergy Clin Immunol. 2013 Nov 23. Pii: S0091-6749(13)01486-3. Doi:10.1016/j.jaci.2013.09.037. PMID: 24280104.
Tse SM, Charland SL, Stanek E, Herrera V, Goldfarb S, Litonjua AA, Weiss ST, Wu AC. Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits. Curr Med Res Opin. 2013 Dec 18. PMID: 24219830.
Kho AT, Sharma S, Qui W, Gaedigk R, Klanderman B, Niu S, Anderson C, Leeder JS, Weiss ST, Tantisira KG. Vitamin D related genes in lung development and asthma pathogenesis. BMC Med Genomics. 2013 Nov 5;6(1):47. PMID: 24121425.
Tse SM, Li L, Butler MG, Fung V, Kharbanda EO, Larkin EK, Vollmer WM, Miroshnik I, Rusinak D, Weiss ST, Lieu T, Wu AC. Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med. 2013 Nov 1; 188(9): 1076-82. Doi: 10.1164/rccm/201306-1017OC. PMID: 24093599.
Wang J, Carvajal-Carmona LG, Chu JH, Zauber AG; APC Trial Collaborators, Kubo M, Matsuda K, Dunlop M, Houlston RS, Sieber O, Lipton L, Gibbs P, Martin NG, Montgomery GW, Young J, Baird PN, Ratain MJ, Nakamura Y, Weiss ST, Tomlinson I, Bertagnolli MM. Germline Variants and Advanced Colorectal Adenomas: Adenoma Prevention with Celecoxib Trial Genome-wide Association Study. Clin Cancer Res. 2013 Dec 1;19(23):6430-7. doi: 10.1158/1078-0432.CCR-13-0550. Epub 2013 Oct 1. PMID: 24084763.
Knight JM, Lee SH, Roberts L, Smith CW, Weiss ST, Kheradmand F, Corry DB . CD11a polymorphisms regulate TH2 cell homing and TH2-related disease. J Allergy Clin Immunol. 2014 Jan;133(1):189-197.e8. doi: 10.1016/j.jaci.2013.03.049. Epub 2013 May 29. PMID: 23726040.
Tse SM, Gold DR, Sordillo JE, Hoffman EB, Gillman MW, Rifas-Shiman SL, Fuhlbrigge AL, Tantisira KG, Weiss ST, Litonjua AA. Diagnostic accuracy of the bronchodilator response in children. J Allergy Clin Immunol. 2013 Sep;132(3):554-559.e5. doi: 10.1016/j.jaci.2013.03.031. Epub 2013 May 14. PMID: 23683464.
Vyhlidal CA, Riffel AK, Haley KJ, Sharma S, Dai H, Tantisira KG, Weiss ST, Leeder JS. Cotinine in human placenta predicts induction of gene expression in fetal tissues. Drug Metab Dispos. 2013 Feb;41(2):305-11. doi: 10.1124/dmd.112.049999. Epub 2012 Dec 3. PMID: 23209192.
Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 Apr;131(4):1176-84. doi: 10.1016/j.jaci.2012.10.002. Epub 2012 Nov 10. PMID: 23146381.

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Scott Weiss, MD, MS

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